General Information

  • ID:  hor006243
  • Uniprot ID:  P84909
  • Protein name:  Prokineticin 1-like protein
  • Gene name:  NA
  • Organism:  Pelophylax saharicus (Sahara frog) (Rana saharica)
  • Family:  AVIT (prokineticin) family
  • Source:  Animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Pelophylax (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0003674 molecular_function
  • GO BP:  GO:0006952 defense response; GO:0032024 positive regulation of insulin secretion
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AVITGACERDVQCGGGTCCAVSLI
  • Length:  24(1-24)
  • Propeptide:  AVITGACERDVQCGGGTCCAVSLI
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates insulin secretion by BRIN-BD11 cells in vitro.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  45857
  • Structure ID:  AF-P84909-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P84909-F1.pdbhor006243_AF2.pdbhor006243_ESM.pdb

Physical Information

Mass: 273717 Formula: C93H160N28O33S4
Absent amino acids: FHKMNPWY Common amino acids: CG
pI: 4.18 Basic residues: 1
Polar residues: 11 Hydrophobic residues: 9
Hydrophobicity: 91.67 Boman Index: -334
Half-Life / Aliphatic Index: 4.4 hour Aliphatic Index: 97.5
Instability Index: 2442.08 Extinction Coefficient cystines: 250
Absorbance 280nm: 10.87

Literature

  • PubMed ID:  16269346
  • Title:  Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog.